Abstract: Background: Primary hyperparathyroidism is a frequent endocrine disorder with variable clinical manifestation and outcome. This study aimed to evaluate the impact of parathyroidectomy on quality of life and symptom relief in primary hyperparathyroidism patients. Materials and Methods: A Cross sectional study was conducted in the Head and Neck Surgery Division of the Department of Otolaryngology-Head & Neck Surgery, BSMMU, Shahbag, Dhaka from August 2022 to January 2023. 25 patients undergone parathyroidectomy. Parathyroid function was measured as parathyroid hormone (PTH) level. Baseline levels of PTH, and total calcium (Ca) were evaluated preoperatively and their postoperative levels were measured before skin incision, 10 minutes after parathyroidectomy, 24 hours and 7 days accordingly. The data was calculated in an Excel spreadsheet which was then exported to SPSS 26.0 (Statistical Package for the Social Science) for analysis. The statistical significance was set to p<0.05. Results: In this series, 3(8.5%), 6 (17.1%) and 2(5.7%) patients presented with osteitis fibrosacystica, nephrolithiasis and neuropsychiatric syndrome respectively. Moreover, 14 (40.0%) patients had muscle weakness, and 18 (51.0%) subjects presented with fatigue. It was observed that preoperative PTH and calcium levels and postoperative calcium levels in SPHPT and ASPHPT were statistically significant. A notable improvement in health-related quality of life was observed with the VAS score rising from 70 (IQR: 50-80) to 80 (IQR: 70-90). Conclusion: This study provides evidence supporting the enduring advantages of parathyroidectomy in individuals with primary hyperparathyroidism (PHPT). The observed reduction in pre-operative symptoms seems to be a significant factor contributing to the enhanced quality of life (QOL) experienced by these patients over the long term.